Clinical Pharmacodynamics - a key component in the drug development process.
One of the key components of translational research in the pharmaceutical industry is the application of pharmacodynamic (PD) assessments in both healthy volunteers and patients. These can play a pivotal role in accelerating the early drug development process, providing valuable information on putative efficacy, dose response and time course of effects.
PD assessments fall into two main categories:
Experimental Models: Symptoms of a particular disorder are induced under controlled conditions so that potential efficacy can be investigated in a “clean” manner.
Pharmacodynamic Techniques: Measure the effects of a drug on the body and can be used to demonstrate target engagement, determine drug response, investigate potential adverse effects and track the progress of a disease.
Clinical Pharmacodynamics at MAC Clinical Research
Scientists at MAC have extensive experience in the set-up, validation and execution of a wide range of PD models and techniques and in their application in early phase clinical research. This includes incorporating assessments into initial Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) studies and larger scale phase 2/3 trials, as well as performing complex stand-alone PD studies.
The table above details some of the most widely used clinical pharmacodynamic models and techniques. However, we are also able to offer assessments in other therapeutic areas including anxiety and appetite control if required.
If you would like to discuss your translational research requirements with MAC please Contact Us:
Excellent collaborative links with local imaging centres allow MAC access to state of the art imaging techniques which can be combined with PD assessments to provide in depth information about the disease progression or the activity of a compound.