Clinical Assessments

Clinical Assessments

Scientific Services and Endpoint Assessments

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Scientists at MAC have extensive experience in the set-up, validation and execution of a wide range of scientific assessments and techniques. These methods can be applied in early or late phase clinical research.

Nurse with patient during clinical assessment

MAC Clinical Research provides a range of scientific assessments:

  • Automated office blood pressure (AOBP)
  • Home blood pressure monitoring (HBPM)
  • DXA scan (dual-energy X-ray absorptiometry): fat mass measurement in correlation with CVD events/risks
  • Echocardiogram (ultrasound of the heart)
  • Blood tests (e.g. cholesterol/triglycerides, BNP)
  • 6MWT (6-minute walk test)
  • Telemetry
  • 24-hour blood pressure holter (wearable)
  • 24-hour blood pressure assessments
  • Electrocardiogram (ECG) assessments
  • QT and QT-waiver studies

Standardised areas of clinical and cognitive rating assessments include:

  • Addiction
  • Agitation
  • Aggression
  • Anxiety (Generalised Anxiety Disorder, Social Anxiety)
  • Autism Spectrum Disorder (ASD)
  • Bipolar Disorder I and II
  • Cognition
  • Delirium
  • Dementia
  • Eating disorders (Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder)
  • Major Depressive Disorder (MDD)
  • Obsessive-Compulsive Disorder (OCD)
  • Panic Disorder
  • Post-Traumatic Stress Disorder (PTSD)
  • Sleep Assessments
  • Suicidality
  • Patient-Reported Outcomes (PROs)

 

Our dedicated rating team, comprised of psychiatrists, clinical psychologists, specialist nurses, and therapists, use recognised and gold-standard testing along with their own clinical assessment experience for initial screening of participants, using assessments such as: Structured Clinical Interview for DSM-V (SCID), Mini-International Neuropsychiatric Interview (MINI) and rating scales, including but not limited to: MMSE, HDRS, CSSRS, SAPS, CDR, HTVL-R, WMS-IV, MADRS, CGI-I, CGI-S, GCAS, SIGMA, HAMD-17, HAM-A, SIGH-D/A, GDS, KSS, EQ-5D-5L, ZBI, BPST-D, GCAS, NIP, FCSRT, AMT, Ishihara Colour Test, GDS, Sentence Completion Test, ABS, IQ tests, CAT, CAPs, HRS CANTAB, CogState.

  • Skin rating scales (SCORAD, EASI, vIGA-AD, PASI, BSA, PGA)
  • Skin-punch biopsies
  • Ultrasound
  • Laser Doppler
  • Functional magnetic resonance imaging (fMRI)
  • Positron emission tomography (PET)
  • High-resolution computed tomography (HRCT)
  • Magnetic resonance spectroscopy (MRS)
  • Nuclear medicine
  • Laser-guided injection
  • Intra-articular temperature probes
  • Electroencephalogram (EEG):
    • Routine
    • Sleep-Deprived
    • Ambulatory
    • Quantitative
  • Sleep assessments:
    • Polysomnography
    • (PSG)
    • Multiple Sleep Latency Test (MSLT)
    • Maintenance of Wakefulness Test (MWT)
  • Actigraphy
  • Electromyography
  • Nerve conduction studies
  • Microneurography
  • Evoked potentials
  • Quantitative sensory testing
    • Thermal thresholds/tolerance
    • Pressure pain thresholds/tolerance
    • Stimulus-induced pain
    • Pain matching
    • Hyperalgesia/allodynia
  • Nerve conduction
  • Saccadic eye movements (oculography)
  • Pupillometry
  • Postural stability
  • Respiratory function testing
  • Bleeding time
  • ExNO
  • Platelet aggregometry
  • RigiScan
  • Minor starch iodine test
  • PH monitoring
  • Peak-flow
  • Flow loops
  • Transfer factors in respiratory
  • Infrared skin temperature
  • pH monitoring
  • Pulmonary function tests
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